We have 6 days in Rome. What can we see in that amount of time. Should be travel somewhere for a day ? Happy to train it, hire a car or fly. We want an italian experience. We are there first week in march.

That is a nice amount of time to spend in Rome, where there is so much to see. It is too much for people here to type out for you since you need to buy a guidebook anyway. There are lots of good ones specifically for Rome that include information about day trips. It is better to use trains and buses.

If you want an "Italian" experience, don't rush around looking at a clock all the time.

My approach to Rome has always been to allow a morning per 'big' site, then a slow lunch somewhere, and then spend the later afternoon exploring different parts of the city with stops for coffee, shopping and so forth.

Big sights might include:

Forum and Colosseum
Vatican and St Peters (though the Vatican museum is often quieter in the afternoons)
Capitoline Museums
Exploring Trastevere and its churches
Day trip to Ostia Antica or Hadrians Villa

Afternoon wanderings might include Spanish Steps and shopping streets round Via Condotti
Borghese Gardens and Borghese Gallery (1 1/2 hours prebooking required)
Piazza del Popolo
Trevi Fountain
Piazza Navona and Pantheon

There are dozens of other museums, depending on your level of interest. Go exploring!

It would help to know who "we" are and what your interests area.

Of course you an find a list of the basics in any guidebook (how many have you looked at?) - as well as the destinations section here.

But how are we to know what YOU want to do? Basic sightseeing, wine tasting, fine dining, history, architecture, shopping, clog dancing, river rafting, mountain climbing?????

We don't know if you are a group of students, parents with 4 kids or a senior couple.

We are not mind readers. Help a little!

Since you want an "Italian" experience, plan to have long, lazy meals that include several of glasses of wine, with dinner starting after 9 pm.

Welcome to Fodors. You have asked what to do in Brussels and what to do in Rome. Fodorites can certainly help you -- but honestly you really do need to get a guidebook or two.

What any of us would do might not be interesting for you. We can help prioritize things, and help w/ logistics . . . but you need to put in a little effort yourself.