Driving from Prague to Telc, Cesky Krumlov to Budapest. Would appreciate tips as to the road trip. Suggestions as to best rental car companies.
While in Prague I am staying at the Kampa Gardens Hotel in Kampa Island. Would appreciate comments.
Any suggestions as to day trips? Maybe two destinations. We are staying 5 days in Prague.
Thank you.

Since you are going south anyway, obviously the day trips should be right around Prague or other direction -- so, my top choice would be Kutna Hora, then perhaps Karlovy Vary. There are a couple castles you can go to, also, I haven't been there, though -- Karlsteijn and Konopiste.

I second Kutna Hora.

For way more CZ info than you can stomach search under "turnip" for my excessively long trip report.

Cheers, the turnip

Alexray,
We will be at the Hotel Kampa Garden from May 11-15. When will you be there. We are from Palm Beach County, Fl. Hope the hotel is as nice as the reviews say.

I'm going to go ahead and tag this.
I too will be there in May,second week.