A sultry port town on the Río Amazonas, Iquitos is quite probably the world's largest city that cannot be reached by road. The city has nearly 500,000 inhabitants and is the capital of the vast Loreto department. The area around Iquitos was first inhabited by small, independent Amazonian tribes. In the 1500s Jesuit missionaries began adventuring in the area, trying to Christianize the local population, but the city wasn't officially founded until 1757.
Iquitos saw unprecedented growth and opulence during the rubber boom, but became an Amazonian backwater overnight when the boom went bust. The economy slouched along, barely sustaining itself with logging and exotic-animal exports. Then, in the early 1970s, petroleum was discovered. The black gold, along with ecotourism and logging, have since become the backbone of the region's economy, though drug running also provides significant income.
The city's historic center stretches along a lagoon formed by the Río Itaya, near the confluence of the Río Nanay and the Río Amazonas. Most of its historic buildings, hotels, restaurants, and banks are within blocks of the Plaza de Armas, the main square, and the nearby Malecón Maldonado riverwalk.