Any good family restaurant suggestions in San Diego or in Mission Valley area?

Consider going to Old Town for kid friendly outdoor dining, either Casa de Pico, Case de Bandini, or Old Town Mexican Cafe (OTMC not outdoors).

Also, there are plenty of familiar chains in the MV area.

old town is a good suggestion.
there is a "tjif" in mission valley. varied menu. can be quite noisy but at least if your kids will blend in. it can get very busy on weekend nights for dinner so go around 4:30 so you don't have to stand in line.
there are lots of fast food places in mission valley - wendys, rubios (so good), etc.

Try Seau's in Mission Valley Shopping Center. If you have boys and are into football sometimes you can see Junior their himself. He's there a lot so are other San Diego Chargers- I think they et free food there or something. It's a nicer upscale sports bar with lots of games going on but not too noisy. Lots of families at lunchtime.

Trophy's in the Hazard Center is good. Also a sports theme, but more baseball than anything else. Probably because it's owned by former major league baseball players. There's a California Pizza Kitchen in the Fashion Valley mall, close to the theaters.