Hello!

A friend is going to San Francisco in early November w/ three friends and would like to stay at a hotel that has 2 bedroom suites. Anyone suggestions?

Try Collow Hollow Inn & Suites (http://www.cowhollowsuites.com/. Nice neighborhood and very clean/comfortable suites for reasonable price.

You may want to see if there is a Residence Inn somewhere close. Residence Inns have studios, one bedroom and two bedroom suites.
There is usually a sofa sleeper in all three room types. You will also recieve a complimentary hot breakfast.

We've stayed at Cow Hollow Suites a couple of times and loved it. The time there were four of us we had a two bedroom/2 bath suite. One bedroom actually had two queen (or was it king?) canopy beds and the other bedroom had a king. The huge living room had a fireplace, comfortable seating, and nice decor including a few antiques. It's like a small private apartment building and the door goes out to Chestnut Street. The bus is less than a block away, or if you have a car there is free underground parking with keyed elevator up to your suite. It's also a great street for boutique shopping and good restaurants.

Thanks for the idea. My friend just told me that she wants to stay in Union Square. Any ideas? Perhaps hotels that have adjoining rooms?

Hi enjoylife, I would imagine some of the better Union Sq. hotels have suites but they would be very expensive. I have stayed at the Fairmont Hotel on NobHills with friends. We had a suite that had a living room and two bedrooms with ensuite bathrooms. I would imagine that various hotels in Union Square do have adjoining rooms. But when I have been in SF with friends and we have had two rooms we have not had a problem with the rooms not being adjoining.

The Beresford (or a sister property) used to have 2-bdrm suites, I think, and kitchenettes. Can't vouch for the room condition, because it's been years since we were there.
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Try the Handlery. They have "club rooms", don't know if they have 2-bedrooms, though. The hotel is on Geary, across from the St. Francis and 1/2 block from Union Square. The club rooms are in a separate section on the other side of a protected swimming pool.