We will be spending a few days in Lake Tahoe and then driving to Yosemite. I need your advise as to where to fly into and out of. We live in Florida.
Thanks,

Clau

Open jaw to Reno and depart from Sacramento or Oakland.

>> . . . and depart from Sacramento or Oakland

Reno is closest, but even round trip in/out of Sacramento wouldn't be a bad option. 2 hours to Tahoe and about 6 from Yosemite Valley.

Since you want to see Tahoe first, I agree with boom_boom. Fly to Sacramento, rent the car, and see Tahoe.
If you are coming in the summer, you could go through Carson City and south on US395 and use the East entrance to Yosemite over the Tioga Pass. The Tioga Pass is usually closed with snow until sometime in June. On the return, go to Merced and up I-5 to Sacramento and the airport.
If you wanted to see Yosemite first, flying/renting at Fresno is another option (south entrance.)

I think boom_boom has overestimated how long the drive is from Yosemite Valley to Sacramento aiport. I would expect that drive to take no more than 4 hours. It's really just over 180 miles from the valley to the airport but due to the speed limit on the road from the valley to 99 you need to add more than the 3 hours it would take on a typical California road to travel 180 miles. I think 4 hours is about right.

You could also fly in and out of Reno as well. The drive on 395 is very nice during the summer.

I live in the Sacramento area. We have driven to Yosemite via 99 and returned via 49. Much preferred the 49 route. Kids might be interested in seeing the old Gold mining towns along the route, especially Columbia. About 9 miles outside of San Andreas is the California Caverns. Really cool..literally!

It takes about 4 hours with no stops (except gas or restroom) to go from Yosemite to Sacramento area.

I went to Tahoe via Reno, rented a car, we stayed in S Lake Tahoe for a week, we had planned on going to San Fran which we did, easy, nice drive. I am from Florida too.
The mountains are beautiful. We also had planned on Yosemite and were advised to spend the night, long drive but for Florida Crackers it was stuff we never see, we booked a room in Lee Vining right down the road from one of the Yosemite gates, Lee Vining is a really small town, the hotel was a mom and pop but clean and the views from the room were magnificant. Be sure and go to the Whoa Nellie Deli at the gas station, the food was great, live music, we really enjoyed it.