My husband & I will be in Spain for 3 weeks in late September-early October for a first time trip to Spain. I'm looking for 3-4 star hotels-cost $150 to $200 US dollars, charming, easy & safe to walk places in day or evening. Madrid for 6 nights, Sevilla for 5 nights, San Sebastian for 4 nights and Barcelona for 4 nights.

I loved my stay at La Casa de la Juderia a couple of years ago, when I visited Seville. Great location, charming hotel that's very comfortable.
Can't help you with San Sebastian or Madrid. I stayed at the Tryp Ambassador in Madrid which was fine & very reasonable but don't know whether it falls in the 4* category.

You will find more help on the Europe board....

¡Suerte y buen viaje!

I know. I always forget to look at which forum I'm in. I did post it on Europe also, but so far no responses. mdm thanks, that's the hotel I was most interested in. It's more thanI wanted to pay, but it looks so good. Did you by any chance check out Las Casas de los Mercaderes while you were there?

Unfortunately I don't know much about the hotel you mention. I hope you will get a rate that's within your budget for Casa de la Juderia... It's a lovely place.