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Lima to Cuzco

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I am going to arrange trip from Lima to Cuzco but would not prefer to go by flight. I want to take bus but there is one problem , It is 21 hours journey and i don't want to be on bus for 21 hours.
If anyone help me that it is possible to break this journey into twice means stay somewhere overnight and then continue my journey.

Any suggestion would be high appreciated. ?

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