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Tuscany & Umbria Self Drive - 2 weeks

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Hello, I am looking for some guidance on scenic driving routes through Tuscany and Umbria from Rome. My husband and I are planning a 2 week trip to Italy the end of April, beginning of May (tentative 4/18 to 5/2). This is our first visit to Italy, and we're completely flexible on our dates, we're looking at cheapest flights to Rome from Miami, and building our itinerary that way. We love adventure driving and discovering off the beaten path places, hiking, and avoiding the tourists/tourist traps, and savoring the culture, food and people.

Through the forums I've read recommendations for the most scenic drives in Tuscany (1) the Chiantigiana route through Chianti (2) Via Cassia, scenic route from Siena to Rome (3) Lucca to Barga (we love mountains). Where would you make your home base? What driving routes would you suggest for Umbria? I wanted to split the trip with 5 nights Tuscany and 4 in Umbria, but with all these beautiful scenery on these routes I am on information overload and can't decide!!

To start our trip, we want to begin in Rome and sight see just 2 full days. Then take the train to
Train to visit Civita di Bagnoregio and Orvieto (pick up car rental) and hit the road on or scenic adventure. My first thought for Tuscany was to home base in Chianti and visit Siena and neighboring towns. Then drive to Assisi and spend the remainder of our time doing day trips to Gubbio, Todi, Spoletto, Terni (Cascata delle Marmore). But now I've recently learned about Lucca and Barga - with the Apuan Alps, I am afraid of spreading our trip so thin we see lots of places but not enough time to savor them.

Any help for what cities to overnight in as a base, or split, and suggestion on itinerary would be really appreciated. Thank you!!

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