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medical opinion malarone vs mefloquine?

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My husband and I have been to different travel clinics to get our shots and prescriptions for our trip in June. Both clinic doctors recommended similar vaccinations (yellow fever, hep A, hep B, tetanus, polio, typhoid and measles/mumps/rubella booster update for me not him).

The interesting difference is that one doctor is very pro-malarone for malaria meds because of lack of side effects, while the other is anti-malarone, pro-mefloquine because he feels there is not yet sufficient evidence from the field that malarone works as well/better than mefloquine and that that outweighs the potential side effects.

Our current opinion is we should leave things as they are since many travellers have been fine with both of them and we believe that both travel clinics/doctors are very competent, but has anyone out there had a similar dilemma? Particularly any other medical opinions or medical references I can look up? I currently have the malarone prescription and my husband has the mefloquine, if male vs. female makes a difference.

Also, I believe my husband starts the mefloquine a week before the trip - if he has a bad reaction to the first dose, will he have a problem going to a doctor and getting a malarone prescription so close to date of travel? Any problem with changing medication after the one dose?

Advice from the board suggests that taking mefloquine with food will help cut down potential problems - any other advice?

Thanks very much for your help!

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