Spanish and the West's subsequent development, Santa Fe became the place to exchange silver from Mexico and natural resources from New Mexico for manufactured goods, whiskey, and greenbacks from the United States. The construction of the railroad in 1880 brought Santa Fe access to all kinds of manufactured goods.

The trading legacy remains, but now Downtown Santa Fe caters increasingly to those looking for handmade furniture and crafts, and bespoke apparel and accessories. Sure, a few chains have moved in and a handful of fairly tatty souvenir shops still proliferate, but shopping in Santa Fe consists mostly of high-quality, one-of-a-kind independent stores. Canyon Road, packed with internationally acclaimed galleries, is the perfect place to browse for art and collectibles. The Downtown blocks around the Plaza have unusual gift and curio shops, as well as clothiers and shoe stores that range from theatrical to conventional. You’ll find quite a few art galleries here, too. The hip, revitalized Railyard District (sometimes referred to as the Guadalupe District), less touristy than the Plaza, is on Downtown's southwest perimeter and includes a wide-ranging mix of trendy boutiques, gift shops, and avant-garde contemporary art galleries—it’s arguably the most eclectic of Santa Fe’s shopping areas.