Hotel Regency
Though it's just 15 minutes from the Accademia and Michelangelo's David, this hotel—in a 19th-century mansion adorned with rich fabrics and period-appropriate furnishings—is a true retreat from the city's noise and crowds. The restaurant here is equally sophisticated, and the Piazza d'Azeglio, a small public park across the street, also evokes 19th-century Europe.