We will be staying at the Manchester Grand Hyatt and looking for a nice restaurant with view for our last night and to celebrate our 30th wedding anniversary. We will have a car, so able to drive. We don't eat meat, do eat fish ie salmon, mahi, tuna, halibut, but not shellfish.

Look at the Fish Market. Upstairs is upscale restaurant with a great view of the Harbor plus the USS Midway. I really enjoy downstairs but upstairs is more upscale and quiet.

Check out Bertrand at Mister A's and ask for a seat by the windows. We've eaten there twice when we were in San Diego. It's quite expensive but the views are magnificient. Here's their website.
http://www.bertrandatmisteras.com/

Drive to La Jolla and go to George's at the Cove. Nice views and good food. It's also in the heart of La Jolla Village so you can walk around before or after dinner.

Congratulations on your 30 year anniversary!

You're in luck- the possibilities are endless. I am sure you'll have plenty of recommendations.

Very popular and highly recommended in La Jolla-

http://www.georgesatthecove.com/

On Harbor Island with gorgeous views of the skyline & Coronado bridge-Island Prime/C level Lounge.

http://www.cohnrestaurants.com/restaurants/islandprime/

And for historic charm- 1500 Ocean at Hotel del Coronado on Coronado Island.

http://www.hoteldel.com/dining.aspx

thanks for suggestions. I did have a reservation at Poehes, but the reviews on Trip Advisor were terrible. Has anyone eaten there?

I'll second Bertrand at Mr A's and upstairs at the Fish Market.