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How much do you want to spend? Pick an area where you think you would like to stay: Times Square, SOHO, Greenwich Village, Tribeca Upper west side, east side - nightlife in all of these areas.
I just returned from the Essex House (Westin) at Central Park South. Got a $199 rate at the Westin website. I'd recommend it! I've also stayed at the Omni Berkshire, Parker Meridien and JW Marriott. All are nice.