I know...unusual destination..we have a business meeting there on Monday...best route please? I have done google maps and mapquest and they are different...somewhat

If you stay in Ellicottville per your other post... mapquest will guide the way...

Buffalo to Syracuse
81 south out of Syracuse to 80 West
Berwick is about 5 miles off of Interstate 80.

Really?? When i did the mapquest or google map they have us going south at Batavia, 390 ish, through Williamsport, etc. Is this all wrong?

I haven't been on 15 from Corning to Williamsport in years, but I don't think it is the greatest or fastest road. Maybe someone else with better knowledge could answer???

US15 is fine. I-81 is a LONG detour.

The only question is whether to take the Thruway to I-390 then south; or take NY400 to US20A to get to I-390.

rkhan...yes, google maps said the 400 one and mapquest said south at Batavia to 390..they are 30 minutes difference in time but I really don't know how the roads are...as well, my husband just bought a car with GPS..not specifically for this trip, ha,ha...but maybe that will help?

US15 is not an interstate, but it's still a good road. It's more winding than I-81, but I have driven a 18-wheeler over it with no issues that I can remember.

If it's snowing or whether is bad, then take the interstate. If you don't like roads with any curves - hey, I lived in Houston for a long time and many drivers don't know how to drive on curvy roads at all! - then take the interstate.