If it's just about wine tasting, and if you stay two or three days in Orbetello, even ten days might be sufficient, technically (note that I said sufficient, not satisfying). If you wish to visit also what is around in terms of art and architecture, you might easily extend that trip to one month.>>

personally I could stay forever, DH likes trips that end after about 10 days. so i would like a little wine, a bit of art and architecture, some good food - not much really!!! probably stay in 3 places max, one in Umbria itself [sadly more or less unknown to me except Orvieto] one further east, and then Orbetello.

too many places, too little time.

but we can always come back.

cornelius - I'd love the name of the agriturismo you mention. thank you.

It is called La Tavola Marche. check out their website. Owned by a delightful American couple who are the best hosts and food to die for!

If you want to discover wineries, France is the place to go. The biggest and most renowned wine region in France is the Languedoc Roussillon near Montpellier and Carcassonne. It is also the leading organic wine producing region and currently is producing some of the best wines in France. Plenty of castles, vineyards and wineries, beautiful landscapes, sights to see, beaches, and of course fabulous food.

Oh, the lobbyists are moving in! The most renowned wine region in France is the Languedoc Roussillon?

And strelac, you useD that limousine service? Why past tense? You're using it every day, after all, it's your company!

Thought Bordeaux was one of the most renowned wine regions or Champagne or Chateauneuf du Pape.

Your question is too open ended. Two weeks spanning Rome to Paris by train with unknown amounts of time to the big cities (what cities-Rome, Paris, ? ). You have given us no info on the types of wine you like or the regions that interest you. We can all laud the experiences of Tuscany, Umbria, Piedmont, southern Rhone, northern Rhone, Burgundy, Alsace and others. All those places have their fans and good points but what of you? Do you really expect to visit wineries on a train route?

This is another of those inquiries that are difficult to respond to without being snarky. I'd love to hear of reasonable suggestions but you must be more willing to provide at least skeletal information.

Well, frankly, I think in the meantime, we can stop posting on this thread. The OP obviously never came back to see what people have been answering to the question.