Hello. I always get such good advice here, I'm hoping that I can get a little input on an itinerary I'm planning for late April and early May.

Any thoughts or suggestions are welcome. Note - I've been to Rome and Florence before, so I have done the main sights and will just be revisiting some of my favorite spots and relaxing in cafes. I will not be renting a car, so I need to rely on trains and tours. My interests are: art, architecture, music (love Italian opera), nature and gardens, nature walks/hiking.

Here is what I am thinking:

Day 1 (April 22): Arrive Rome / check into hotel in Central Rome
Day 2: Borghese Gallery tour, explore the surrounding gardens
Day 3: possibly the Vatican Museums again, but open to other art and architecture experiences (I've done ancient Rome on two previous visits, so I'd prefer something less crowded and touristy)
Day 4: Train to Perugia (this is my base for 5 nights for daytrips to Assisi, Spello and/or Spoleto) Any suggestions for these days?
Day 9: Train to Florence this is my base for 5 nights to revisit favorite places and do daytrips to Siena, San Gimignano, Lucca and possibly Pisa) Any suggestions for these days?
Day 14: Train to Rome airport for overnight before flight
Day 15: Flight back to the US

Thanks in advance for your thoughts.

Hi Rowdygodwin1975. When you wrote Pulia, did you mean Perugia? My late hub and I visited Assisi and Spello by train from our: Spoleto base. Spello train station was unmanned at that time! Here's my TR:

https://www.fodors.com/community/europe/turin-spoleto-bologna-and-bellagio-tr-947180/

Scroll down to March 16 for Spoleto. Please share your experiences!

Yes. I did mean Perugia. Sorry. I have updated it above.

This very recent thread offers a lot of great ideas for Rome beyond the basics:

Rome Beyond the Obvious: Things to See, Things to Do

Have not visited Spoleto, but Spello would get my vote as your base by a country mile over Assisi. Aside from the issue of the distance between Assisi’s train station and the town proper, its restaurants and hotels seem to suffer from that “We know you’ll only be here once, so why try to impress you?” syndrome.

There are some great walks all around Mt Subasio.

I agree with FTOttowa about travel from Assisi, but unless things changed, Spoleto's train station is manned and Spello's is not... difficult for travelers not familiar with Italy. The flower festival in Spello is a don't miss!