PalenQ

Airport Rome to Florence first day would take about only 3 hours all told and there are car transfers too.

AnnJK

Hi, we chose the Amalfi coast over Cinque Terre. Take a look at my Italy blog for ideas https://www.diyfamilytravels.com/category/italy/

PalenQ

I'd go with Amalfi too over CT - bit less crowded and you can take boats to Capri or Ischia or Salerno (for Paestum), etc.

If not into hiking CT is just a bunch of terribly mobbed some towns.

PalenQ

Amalfi though for OP takes too long to get there and for a day or two not worth it - a day or two in CT is enough for most.