Is it better to visit the Accademia Gallery in Florence on a Friday or Saturday (2 adults)? And what is the best time of day to visit? Thank you.

I think your time of year is more important than Fri or Sat. Also, are you reserving in advance?

We reserved in advance for late June. Selected Sunday since essentially stores are closed on Sunday so we'll stay in Florence that day and visit sights such as Accademia, Synagogue, Piazza Michaelangelo, maybe Fiesole.

First week of June...with advanced reservations.

Reserve in advance absolutely as the lines can be very long.

I will reserve in advance, but my original question still stands: Is it better to visit the Accademia Gallery in Florence on a Friday or Saturday (2 adults)? And what is the best time of day to visit? Thank you.

Late afternoon when the day trippers have gone IMO and the day would not matter.

OR an early morning entry time before the tour groups arrive, either day.

I don't think there is any difference between Friday or Saturday.
We usually try to go first thing in the morning. If you cannot get an early reservation late afternoon is good. We have also had success with a 1:00 p.m. time when many people are at lunch. Mid-morning and around 2:00 p.m. seem to be the worst times.

I reserved Friday morning. Thank you.