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San Francisco-wine country holiday planning

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We're hoping for some help please with our plan to visit San Francisco and the wine country for 10 days in September-October this year.
The 10 days would include several days in San Francisco itself - we're thinking at least five days in a self-catering apartment, but would appreciate suggestions regarding length of stay and areas for such accommodation in the city. We'd also like to visit the wine country and were thinking of basing ourselves in Healdsburg. We would like to visit Sausalito, Half Moon Bay and Carmel, but would be interested to hear any other suggestions.
We'd rent a car for part of the holiday, but were wondering what about the best way to approach this to avoid backtracking. Perhaps San Francisco first, initially without a car and then pick up the car, do day trips to Sausalito and Half Moon Bay, overnight in Carmel and then head out to Healdsburg?
Any help would be appreciated. We are coming from Cheltenham in England.
Thank you

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