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Need advice on train travel vs. rental car (DC/Baltimore/NYC trip)

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I desperately need some advice on how to manage ground transportation for this trip. I usually do much more research on my own but with a two year old and an infant with medical needs it is really hard to find much computer time. ANY advice I could get would be much appreciated!

We are traveling to DC, Baltimore and NYC in October for medical appointments for my infant daughter. Traveling will be my husband and myself, our 8 month old and 2 year old daughters and my parents who will watch my 2 year old while we are in medical appointments. We are going in and out of National as we purchased the non-refundable, super cheap tickets when we were only doing the DC/Baltimore leg and didn’t know about the conference in NYC. Now we really need to go to the conference too.
Here’s what I have so far (and note the dates are set in stone as they are for medical appointments for my daughter and the Vascular Birthmark Conference in NYC)

Saturday: Arrive National Airport 6:25 pm
Sunday: Free day in DC
Monday: 8:00 am appointment in DC
Tuesday: 11:00 am and 2 pm appointments at Hopkins in Baltimore
Wednesday: 10:00 am appointment at Hopkins in Baltimore
Thursday ???
Friday: to NYC/Shelbourne Affinia hotel (free night stay from conference)
Saturday: 8:00 am conference at NYU followed by (hopefully but may be later) 1-2 pm clinic appointment
Head back to DC after appointment and overnight in DC
Sunday: 2:00 pm flight out of National

So my main question is when we should rent the car and when we should attempt to use trains. I would love to take the train between Baltimore and NY and NY back to DC as it is a long time for the girls to sit in a car. A train trip will be much easier for 2 year old to be entertained (we take the train to San Diego frequently with her and she loves it). But having to lug two carseats around on the train (as we would need them for rental cars) is a nightmare (did it in Spain with ONE and said never again). Would it be a impossible to do the whole thing via trains? Or should we rent a car on either Monday evening or Tuesday morning in DC to go to Baltimore, keep it in Baltimore and leave town after appointment on Wednesday and go somewhere else then head into NY on Friday and turn the car in there?

Thank you for any thoughts!!!!

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