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Driving from Durham, NC to Tennessee

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At the end of April I am spending 6 days driving with my daughter from Duke University in Durham, North Carolina to Nashville, Tennessee. I would like some ideas of cute towns with fun downtown areas with boutiques/restaurants in western North Carolina and Tennessee on the way from Durham to Nashville. Also, once we are in Nashville, what other cities are worthwhile to visit in Tennessee? We mostly like shopping and cute restaurants, but no huge malls (as we are from Los Angeles) Thanks and just want to have an itinerary for the 6 days including from Durham,NC to Nashville.

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