4 Best Hotels in Salta and San Lorenzo, The Northwest

This elegant 10-room abode represents Salta, right down to the cardon cactus door panels and hand-stitched headboards depicting Andean landscapes. Comfortable en suite guest rooms, each named after a national park, have terraces and some boast a poolside view. You can lounge in the living room with a glass of Torrontés after a long day of sightseeing.

Sister to the Buenos Aires hotel of the same name, the family-run Legado Mítico attends to every detail—from the gorgeous guest rooms named after notable figures from the city's past and individually decorated to suit the titular person right down to the welcome glass of wine. Shared areas, hung with artworks by the owners' mother, Norma Adamo, are extremely inviting.

Despite appearances, this striking Georgian-style mansion only dates from the 1980s, when it was built as a private home. It still feels like one, with bright and airy rooms in the main house and in a guesthouse with huge windows, hardwood floors, and period furniture. The dark-wood-paneled penthouse suite has a vaulted ceiling; two of the double rooms in the guesthouse share a sitting room, making them ideal for a family or group.

The exterior of this beautiful old house belies the modern comforts within; an elegant lobby leads to a tastefully appointed sitting room, an airy courtyard, and a good (though expensive) restaurant. The rooftop pool area has great city views. The slightly pricier superior rooms have balconies overlooking a quiet plaza; suites have Jacuzzis.