you like elegant flagships and money is no object, head to Midtown, where you'll find international megabrands like Louis Vuitton, Yves Saint Laurent, and Gucci, as well as famed department stores Bergdorf Goodman and Barneys. Nearby Madison Avenue has couture from Carolina Herrera and Vera Wang, and 5th Avenue is lined with famous jewelry stores like Tiffany, Van Cleef & Arpels, and Harry Winston. This is also the neighborhood to indulge in bespoke goods, such as handmade shoes from John Lobb. If you like designer pieces but can't afford them, don't despair—there are plenty of upscale consignment shops around the city where you can find last season's Chanel suit or a vintage YSL jacket.

The small, independent shops that once lined SoHo have largely been displaced by the likes of J.Crew and UNIQLO, but if you want to hit the chains, this is a great place to do it, because the neighborhood also provides high-quality people-watching and superb lunches. Poke around on the side streets and in nearby NoLIta for outposts of smaller local and foreign designers and, if you're craving some of old SoHo's artistic spirit, don't discount the street vendors' stalls, which sell handmade jewelry and simple cotton dresses. You never know—you might buy something from a soon-to-be-famous designer.

The East Village and Lower East Side are hotbeds of creativity and quirky coolness, with little boutiques selling everything from retro furniture to industrial-inspired jewelry tucked among bars and old tenement buildings. The Meatpacking District is another great shopping destination to find chic designer stores like Diane von Furstenberg and Catherine Malandrino along with independently owned boutiques.