Duomo
Severe yet mystical, the Cathedral of San Lorenzo is most famous for being the home of the wedding ring of the Virgin Mary, stolen by the Perugians in 1488 from the nearby town of Chiusi. The ring, kept high up in a red-curtained vault in the chapel immediately to the left of the entrance, is stored under lock and key—15 locks, to be precise—most of the year. It's shown to the public on July 29 (the day it was brought to Perugia) and September 12. The cathedral itself dates from the Middle Ages, and has many additions from the 15th and 16th centuries. The museum displays historical artworks and treasures, plus don't miss walking the underground foundation layers, some of which date to the 7th century BC; book a timeslot online when you buy a ticket.