Margutta 19
At this all-suites property, tucked away on a leafy street known for its art galleries, the amenities are top drawer, the design is contemporary, the restaurant features a verdant terrace, and the accommodations have a hip New York–loft feel. Some suites are in the main building at Via Margutta 19; others are in an annex at Via Margutta 54, which once held studio lofts used by Picasso and other great painters. Travelers looking for a little more privacy or space can rent the entire top floor of the annex, as the rooms are adjoining. These rooms are less expensive than the rooms in the main building, but don't come with breakfast; and note that light sleepers might be able to hear the Metro pass underground at night.