10 Best Restaurants in Avignon and the Vaucluse, Provence

Set in a leafy enclave, on a bustling old town street, this tiny jewel is one of  L'Isles’ best-kept secrets. The menu may be short, but that’s because the chef focuses on selecting the best local, seasonal ingredients as well as on creating picture-perfect presentations. Expect dishes like cod with orange-braised endive and beurre blanc or slow-roasted spiced veal with spinach and Parmesan. With seating for only 18, reservations are a must.

At this gastropub hot spot in the heart of the city, chef Julien Gleize applies light, playful, modern touches to dishes that are steeped in French tradition, made with local ingredients, and beautifully presented. Options might include rabbit farci perfumed with wild cèpes and served over a cloud of whipped potatoes and shallot confit or wild salmon caramelized in olive oil with watercress, black sesame seeds, and luscious cream of corn.

If you're willing to travel 10 minutes to the tiny perched village of Goult, you'll be rewarded with a top-notch, thoroughly French meal at a restaurant that's elegant enough for a celebratory dinner, yet casual enough for a gourmet lunch on the go. Sea-crab soup with fricassee of cuttlefish and homemade aïoli makes a nice prelude to saddle of rabbit with local chanterelle mushrooms stewed with kale (a rarity in France). Top off your meal with a homemade sorbet, pear poached in black current and stuffed with rice pudding, or assorted regional goat cheeses and a local rosé. In summer, try for a seat on the small outdoor terrace overlooking the town square and church.

The more elegant sister to Mathieu Desmaret's locavore mecca, Pollen, this dining room set in a 14th-century cloister attracts a chic, upscale crowd that fits right in with the stunning decor. You'll find all the flair and precision that put this talented chef on the foodie map, but with an Asian touch in dishes like candied beets with miso yogurt and kumquat or roasted pollack with lemongrass, ginger, and lacquered leeks. For a more casual meal of appetizers and wine, with many options available by the glass, head to the wine bar and grab a seat inside or out on the beautiful cobbled terrace; there's also a cocktail bar with a menu of creative libations.

Steps from the Palais des Papes, this chic hot spot is part of the "bistronomy" movement, which focuses on creative cooking, a casual atmosphere, and reasonable prices. The quaint terrace on a side street lures in passersby, and the romantic 17th-century interior courtyard keeps them coming back.

A 200-plus wine list is a big highlight of this restaurant and bar à vins, yet the main focus is squarely on the food. Beautiful to behold and even better to eat, the Mediterranean-inspired dishes flaunt the bounty of Provence in options like beef carpaccio, sliced razor-thin and served with shaved Parmesan and crispy house frites; a tender zucchini tartlette with chèvre and herbes de Provence; or a salad of heirloom tomatoes, bufala mozzarella, Serrano ham, and basil sorbet. A laid-back atmosphere, friendly staff, spacious outdoor terrace, and excellent prices make this a top choice.

Set amid vineyards just outside Orange, this stone farmhouse restaurant recently updated its traditional dining room and its dishes, while maintaining its charm and its high standards. The sophisticated menu is based on the French classics like salmon mousse, house-made foie gras, beef cheeks, and a fish of the day. In warm weather, the terrace is a lovely place to be.

You’re in excellent hands at this wine bar and “bistronomic” (bistro with gastronomic cuisine) dining room helmed by two accomplished chefs and set in a restored 18th-century inn in St-Saturnin-lès-Apt, a hilltop village 9 km (5½ miles) north of Apt. Cozy up to the old-fashioned wooden zinc bar for a homemade pastry and coffee, lunch, a snack, or a glass of wine expertly chosen from the Provence region and beyond. In the refined dining room (or balcony terrace), expect a casual bistro menu at lunch, but at dinnertime the linens and candles come out for a gourmet meal accompanied by spectacular views. All the ingredients, including the meats, artisan cheeses, and market-fresh fruits and veggies support local, sustainable, and organic agriculture.

It's well worth the slog up the hill to the château simply to linger on the terrace of this long-established restaurant and savor the view over Mont Ventoux, Avignon, the Luberon, and the Rhône—and you can visit the restaurant's well-stocked wine cellar on your way to the top. The tarte à la tomate confite with goat cheese and iced white cheese is a specialty that reveals a love for the region's cuisine. The owners, the Estenevins, have lived in Châteauneuf-du-Pape for three generations; Philippe and Jean-Pierre took over the restaurant from their parents.

This restaurant is worth a trip just outside town for such delights as sea bream with cherry tomatoes and flaxseed, a trilogy of goat and ewe cheeses with black-olive jam, or roasted pike perch with risotto. The bistro-Provençal interior and the terrace are the perfect settings for long, leisurely meals, and there are spectacular village views. In addition to several prix-fixe menus (from €30 to €49) there are many à la carte offerings.