Any suggestions on restaurants in Las Vegas that have really great seafood?

Yes,
The Rio Buffet in the hotel of the same name is really something extra special. Even their regular buffet has plenty of seafood but not lobster. The seafood buffet has lobster has well. See the free ceiling show while you are there. It is special too.

The Tillerman restaurant on Flamingo is great, the natives go there.

I second the endorsement of the Tillerman...excellent, nice atmosphere too. On the strip try Emrill's Fish House, I think it's inthe MGM

I live in Las Vegas, and, believe it or not, when I want seafood, I go to Red Lobster. I know, I know, how gauche! And not at all what you were looking for. But remember, Las Vegas is in the middle of the desert! It is NOT known for seafood. If I want seafood, I go somewhere near the sea. Very little seafood in Las Vegas is really fresh (including that at Red Lobster), and Red Lobster has the greatest variety. I know, Red Lobster is NOT what you wanted to hear, but I just wanted to warn you that there is very little really good seafood in LV.

Good evening, Ginny
Have to cast my vote for Buzios' in
the Rio, care is taken with preperation
of the various seafood which are on the
menu for that day, the daily specials.
Richard of LaGrange Park, Il...

AQUA --- this place is awesome...I am quite sure it is in the Bellagio. ENJOY!!! jwg

I gotta agree with Richard about Buzios (sp?). Their seafood is great...and you can sit at the bar and watch the cooks prepare food in these big kettles. Their steamed clams are especially good.

Pat of Chicago, IL

Two AMAZING restaurants that will leave you happy:

AQUA in the Bellagio and
Emeril Legasse's New Orleans Fish House in the MGM.

These are the best seafood places that vegas has to offer, hands down.