I currently live in York, pa. Will be having house guests from Florida for one week in early September. Would like to take day trips (about 100 miles) from York to interesting places and things. Any suggestions would be greatly appreciated.
P.S. They have already visited Pa Dutch Country and Gettysburg.

In the SW PA area there is a lot to see. Frank Lloyd Wrights Fallingwater and Kentuck Knob. Seven Springs resort - check for when the Octoberfest begins. Pgh area - Strip District, the Carnegie and Warhol, Southside for funky shops and dining, Mt. Washington for the 2nd most beautiful view in the country. Steeler game if you can get tickets. Pirate game - who cares about the game enjoy one of the best baseball field in the country. Have fun!

I'm sure you could keep busy in Phila for quite a while.

The Inner Harbor in Baltimore has a lot to offer. The Aquarium is a great place to start. There is a Hard Rock Cafe,ESPN Zone and many more shops and restaurants there. Also, Ft. McHenry is a short water taxi ride away and it is the Fort is free!

Pittsburgh's probably a bit far for a day trip. Although Fallingwater and Kentuck Knob would do nicely. Baltimore's certainly a good bet. In addition to mersingary's highlights, I'd add Lexington Market. Faidley's seafood stand's worth a trip to Baltimore in itself...

Speaking of markets, Roots (Tues., near Manheim) and the Green Dragon (near Ephrata, not sure about the day) might be worth a look.

I'll add an offbeat suggestion: the Pennsylvania Reniassance Faire. It's held on the weekends at the Mount Hope Estate and Winery (just outside of Lebanon), and might be a fun way to fill a weekend afternoon. You could easily couple it with a trip to Hershey.

In Brandywine country in Chester County is the Brandywine River Museum with a great Wyeth art collection, sonderful restaurants and the Brandywine Battlefield. And right down the road is Wilmington, Del., which has some neat museums.
Philadelphia can't be beat for art (Philly Museum of Art, Pa. Academy of Fine Art, Rodin Museum)and history (National Constitution Center, Liberty Bell, so much more). The site gophila.com even has suggested itineraries. Have fun!

Cacapon State Park/Berkeley Springs, WVA is nice. You could return via Harpers Ferry. Also consider taking thr train from Lancaster to downtown Phila.-but be sure to check for family rates ahead of time on Amtrak's website.Luray Caverns and the northern end of Skyline Drive would be beautiful on a nice day. Charlottesville, VA would be great but beyond the day trip limit.

You also might like Chesapeake City, MD located on the canal connecting the Delaware & Chesapeake. Small, quaint and always relaxing.The Lancaster outdoor markets are very popular. Roots in Manheim on Tuesdays & Green dragon on Fridays in Ephrata.

My suggestion would be a day trip to Peddler's Village in Lahaska, Bucks County. Starting September 11th through October 30th is the Scarecrow Festival. I attend this each year and is a great way to kick of the wonderful PA Fall season. Another nice day trip would be Adamstown (appx 15-20 miles from Lancaster). There are some great antique shops to stop in and browse. Green Dragon, which was mentioned in a previous post, is only a few minutes from Adamstown. You could visit both places in the same day. These just a few ideas...have fun!

I second the Peddlers Village idea. Also while in the area you can visit New Hope Pa. It is always crowded and a fun place to walk around.

I'd say do Philly they have great restaurants, the historic district is wonderful.Philly is a great walking town.You can anywhere on foot.You could take in one of the many shows. Its also very safe
p.s. I could recommend one of the tours I recently did if you would like

One of my all time favorite places to visit in Pennsylvania is Longwood Gardens in Lancaster County.


http://www.longwoodgardens.org/

Longwood Gardens is in Chester County and could be coupled with a visit to the Brandywine River Museum since the two are about 5 miles apart. Or you could visit Longwood Gardens and Winterthur both former homes of the duPonts. Winterthur has one of the premier collections of early American furniture in the country. Also, if you visit the museum before 11/19 you can also visit the home and studio of N.C. Wyeth.

Thanks, Suki--my mistake!

Annapolis, MD would be a nice day trip. It is about 85 miles from York. You could either drive direct or take a boat excursion from the Baltimore Inner Harbor. Speaking of the Inner Harbor, if you go there you can get all day water taxi passes. Nearby Fells Point can be fun too. If they are interested in history, Fort McHenry of Star Spangled Banner fame is also near the Inner Harbor. A visit to Annapolis can also be combined with a visit to the Naval Academy. Washington, D.C. is also in your driving range.

Here are several places to consider, all are within the area you mentioned.

http://www.nps.gov/gett/

http://www.nps.gov/anti/

http://www.nps.gov/hafe/

Valley Forge might be interesting. The park is beautiful, with many trails. You could also go to the King of Prussia Mall.

I'd thrown in Doylestown, which is a walkable town with a bit of shopping, nice restaurants, a terrific repertory movie theater (http://www.countytheater.com/) and the James Michener Museum (http://www.michenermuseum.org/)