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It's always a party town, but that time of year is a bit much. A lot of students rent massive trailers that tend to clog the streets and beach areas. Try the Ritz in Naples or Key West before March 15.
March is always a crazy month. The biggest weeks are when the big Fla schools get let out. Stay away from the chain hotel/motels because that is where most stay. Many of the B&Bs do not allow spring breakers so would be you best bet.