Is it be worthwhile to use I295 around Jacksonville rather than driving through on I95?
Any info on Adam's Mark Hotel in Orlando?

ttt

Take 295 and avoid the traffic.

I agree - take 295.

Thanks for your help, I'll do that.

There's another route too. I think it's "15", but don't recall. Visitor center in St. Augustine recommended it to me as quick way to JAX airport when I was down there almost 2 years ago. There was some "on street" driving, but much of it was a new multiple-lane highway- similar to interstate driving. It sure beat the ride on I-95/I-295. Watch for the "drive-time" traffic near Orange Park - very busy.

Maybe some area residents can speak up?

I would take I295 definately.

About the Adam's Mark - this is connected to the Florida Mall. Depending on why you are going, this may not be the best place to stay. It used to be a Sheraton (if I remember correctly). I haven't heard much good/bad about the hotel, except for the location if you are doing Disney.