Hello, my wife and I will be flying to Lisbon in the first week of January. After 4 days, we will be going from Lisbon to Seville where we will rent a car and tour Analusia by car to Granada. There we will drop off the car and train it back to Madrid from where we will fly home. Our trip is 3 weeks long. Thinking of the train from Lisbon to Faro, then a bus from Faro to Seville. Has anyone got any advice to offer on best way to do it? We would prefer to do it in a single day if possible. Or... I was looking at one way car rentals. The prices seem very inexpensive that time of year. Any ideas on perhaps renting a 1 way car in Lisbon? Thanks in advance.

Lisboa - Sevilla:
Direct bus (Flixbus), twice daily 7 hrs journey
train to Faro plus bus to Sevilla, once daily, 7 1/2 hrs journey
flight by TAP, once daily, 4 1/2 hrs door to door
all by train via Merida https://www.spain.info/en/destination/merida/ once daily, 10 hrs journey

I would fly Lisbone to Seville as some low cost offer the route. In Spain the railway network is good and should be expensive as there are several companies operating the network. If you book with enough time you should get a good price. You can compare with Trenes.com or Trabber.com

If train doesn't help, there are several bus companies in Spain such Alsa and others.

I would take the opportunity to see something of the country enroute so would take bus or train.

The OP never came back since about 4 weeks