We want to rent a car for 3 weeks in Europe (Amsterdam) looking for cheap options, also anybody has a clue if it's possible to rent in one country and drop in another?

You can rent in one country and drop in another, if you use a biggish company and are prepared to pay a very hefty one-way drop off fee.
You will need to contact the companies to find out what they charge - you will not find it on their websites, and you will usually pay the fee on picking the car up.

If you are staying in Amsterdam first then hire the car at the end of your stay - you really do not need a car in the city itself. If you are planning trips out from the city and need a car for them plan them for the end of your Amsterdam period and find somewhere else to stay.

Oh and if you decide to make it a round trip to avoid the drop off fees make sure the rental company knows you are taking the car out of the Netherlands.

Thanks we are not going to use the car much in Amsterdam, probably just drive off to Italy via France and drop it in Rome or Pisa. We don't want to break our bank in the process, still exploring public transport and flying options.

Renault eurodrive lease best way to do this in my experience

Europar.com have also done more expensive big one way drop off

Nice in rural areas no fun in big cities big parking charges scary traffic

Espcially in Naples Italy so currently for me point to point train

Usually like a local cheap nice city centre to city centr no hassle.

Seat61.com

"probably just drive off to Italy via France and drop it in Rome or Pisa"

Do you have any experience in driving in Europe? Because Rome is the biggest traffic-diaster you can get yourself into, maybe in all of Europe. I certainly would not reccomend it if you can avoid it...

@Set: Rome really isn't that bad. Try Brussels, Warsaw, London, Paris just to name a few. The Italian traffic may be a bit chaotic but at least you'll be driving. OTOH, Rome has a perfectly good underground public transportation system and the interesting part of Rome is small enough to negotiate on foot. Same for Amsterdam.

Actually, a road-trip is not a bad idea if you want to visit small towns and in general enjoy driving. The Alps are great to drive through, the French highways not so much. However... there's a considerable price to pay.

When driving through Switzerland, Amsterdam - Rome is a ca. 1660km trip (roughly 1000 miles). Depending on the type of car, I reckon you'll spend somewhere between €160 and €250 on fuel (depending on car- and fuel types). Add €35 for a toll vignette in Switzerland and another €40 for toll in Italy. Add €500 rent for a small car for two weeks. Let's say €750 in costs and another €700 or more for drop-off.

Are you still sure you want to drive? A plane-ticket Amsterdam - Rome may cost under €100, including taxes. Or go by train if you must and pay €325 per person for this trip.

Picking up a car in one country and dropping it off in another is going to cost you approximately $500. Bad idea. I'd figure out a way to avoid that.

I also disagree with The_lonely_traveler on two points: 1) driving in Paris is a breeze compared to driving in Rome. For one thing, the city is laid out in a manner that is understandable; Rome is not. For another, Parisian drivers are pretty tame when it comes to being tolerant of strangers driving in their midst; Romans are not. 2) Rome does not have a perfectly good underground public transportation system; the metro in Rome is virtually useless.

At any rate, your plan of picking up a car in one country, driving all over and leaving it in another doesn't make much sense, particularly as you seem to be focusing on cities, where having a car will be a complete burden.

@StCirq: finding your way is hardly an issue with modern navigational aids. My statement about Rome being better than Paris for driving is based on the observation that traffic jams in Paris are much, much worse than Rome. As I said: at least in Rome, the traffic moves along. It is a bit chaotic and might feel unforgiving - but hey, that's basic Italian temperament: howl like the wolves do but don't bite . Just don't panic.

Anyway, it's pretty obvious most large European cities really aren't driver-paradise, not by a long shot. Simple advice: "don't" - I think we do agree on that.