I will be in London for a Friday and Saturday Night only. 27 year old girls, want a safe area and close to tube. Has anyone heard of these:
Collin House Hotel
Elizabeth Hotel
James & Cartref House
Winchester Hotel
Thank you for any advice.

Collin House is in Belgravia; Elizabeth is in Hyde Park; James and Cartref House is also in Belgravia, and the Winchester hotel is also in Belgravia.

As areas go, Belgravia is one of the safest and most desirable. However, it is mainly residential, and lacks a young nightlife style. Not many tube stops - although they don't run after a certain hour. You're better off staying more centrally in Mayfair which has a more age transparent nightlife.

Thanks for the reply. Could you suggest something in Mayfair that won't break the bank

What's your budget?

The Westbury in Conduit St can often be booked very cheaply if you call them and bargain. Or the Holiday Inn Mayfair which is around 80GBP per night for a triple so I'd imagine a double would be slightly less.

There have been lots of posts about using Priceline to get a 4* hotel for under $100 per night. See http://www.biddingfortravel.com and http://www.betterbidding.com and do searches here. Almost certainly you'll get a better value than the hotels you listed.

M kingdom2, Thanks again for reply. The Westbuury looks very nice, I wrote them for prices. Could you explain to me where the tube would be from this hotel.

The Morgan Hotel in Bloomsbury is a good one. I paid 68GBP for a single. It is near a tube stop and close to SOHO and other good nightlife. It also includes full English Breakfast.