Looking for any recommendations of Driving Itineraries of Rural Italy esp Tuscany, Umbria and Le Marche.

This is way too broad a question for any knowledgable person to answer. Narrow it down and maybe you'll get some help.

I could give you a hundred driving itineraries in Tuscany alone, but how many days will you be there, and what is your base, and what do you want to see? These are samples of the questions you need to ask yourself before you ask for the help you need.

Frommers has a whole book on rural driving itineraires in Italy. I have several favorites in Tuscany--do you have the TCI map at 200k scale?

Sorry StCirq - I should have phrased it as Bob replied - I would like to here about some of your favorites. I will have two full weeks and am thinking of a villa rental in late September in two different areas and exploring.
Bob - I would be very interested in some of your favorites - yes I do have detailed maps.

Here are a couple for starters:
SIENA TO MONTEPULCIANO, but via the back roads to include Asciano, Trequanda, Castelmuzio, Santa Anna di Camprena[English Patient site], and Pienza. The Crete Sensei region

MONTALCINO TO SAN QUIRICO, via St. Antimo,Monte Amiata, Castiglione, Bagno Vignoni, and then up to the Abbey at Oliveto Maggiore--or reverse.

Good luck and take your camera !

I have two favorite routes in southern Umbria. From Terni, take the SS209 north along the Nera Valley to Triponzo and then the SS 396 east to Norcia. After visiting Norcia, you can take the SS396 as it swings north toward Preci and hook back up with the SS209. Go north to the SS 77, then west to Foligno where you can take the autostrada back to Terni. This entire drive (except for the autostrada) goes through an area of jaw dropping scenery. A shorter drive starting in Terni would be to take the SS 79 west past Lago di Piediluco, visit the tiny village of Labro and have lunch outside Rivodutri at La Trota, an inn set beside a trout stream that has some of the best food in Italy.