Casa de Uco
You can tell the owner of this luxury hotel is an architect as soon as you enter: majestic views of vineyards and mountains are expertly placed through a series of shapely windows, skylights, and sloping walls, and there's a handsome infinity pool that drops off into the vineyards below. Luxurious linens and interior design make each room feel cozy and some rooms have a view of the Andes right from the bathtub. There's a great restaurant on-site (book the cooking class) and you can explore the 350-acre estate by horseback or bike.