Lancaster Arts Hotel
This boutique hotel in a former tobacco warehouse dating from the 1800s offers sleek rooms furnished with executive desks, flat-screen TVs, iPod docking stations, and free Wi-Fi; there are also whirlpool tubs in the suites. Local artwork—available for purchase—is everywhere, as are exposed brick and stone and chestnut beams. The adjoining restaurant and bar, John J. Jeffries, offers a seasonally driven farm-to-table menu.