It's not every day you can be a "guest" of a famed 17th-century church, but this distinctive B&B was once part of the giant complex of Santa Maria della Sanità, the main landmark of the Sanità quarter. Before visions of gilded frescoes fill your head, keep in mind that this church was erected by the Franciscans: the hotel's decor would please the spartan taste of their patron saint, though modern majolica flooring and art photographs of local street life inject an upbeat flavor. Guest rooms, however, are minimal modern. La Sanità is a lively, sometimes rough neighborhood, busy with scooters and other traffic, but double-glazed windows cut down on the noise. The owner, Sergio, also offers a comfortable apartment sleeping up to six in the same building, runs an excellent trattoria nearby, La Locanda del Monacone, and is also responsible for selling tickets to the catacombs of San Gaudioso, situated next door, and those of San Gennaro.