Hilton Prague
From the outside, this gigantic, 11-floor, glass-and-steel building looks like a throwback to communist Czechoslovakia, but step inside and you'll find a pleasant, modern, and stylish business hotel. The rooms and suites are warm and spacious, with all the modern conveniences; opt for an Executive Room for access to the beautifully renovated Executive Lounge, or go all out with a corner Apartment Suite, complete with either private gym or entertainment room. Outside of the bedrooms, the hotel has an impressive array of dining and drinking options, from restaurants and bistros to beer pubs and cocktail bars, as well as a casino atrium and summertime beer garden. There's also an expansive health club, including an indoor pool, fitness area, sauna, steam room, and various spa treatments on offer. The riverside location is quiet and peaceful, yet it's only a pleasant 20-minute stroll from the hotel to Staroměstské náměstí (Old Town Square).