Fodor's Expert Review Hotel Palazzo Grillo

Formerly the Grillo family palace, this sumptuously comfortable boutique hotel integrates architectural details from the 1500s to the 1700s—like an original marble entryway and staircase, frescoed ceilings, and frieze details in some rooms—with clean-lined modern luxury. All of the furniture has been hand-picked and combines vintage pieces with those from some of Italy's best designers, with an emphasis on minimalism and surprising pops of color. Public spaces such as the ballroom-size living room, billiards room, and top-floor terrace add to the appeal.