When it comes to accommodations, Rome offers a wide selection of high-end hotels, bed-and-breakfasts, designer boutique hotels—options that run the gamut from whimsical to luxurious. Whether you want a simple place to rest your head or a complete cache of exclusive amenities, you have plenty to choose from.
Luxury hotels are justly renowned for sybaritic comfort: postcard views over Roman rooftops, silver flatware on white linen atop a groaning breakfast-buffet table, and the fluffiest towels. But in more modest categories, very often Rome's hotels are not up to the standards of space, comfort, quiet, and service taken for granted in the United States: you’ll still find places with tiny rooms, lumpy beds, and anemic air-conditioning. The good news: if you're flexible, there are happy mediums aplenty.
One thing to figure out before you arrive is which neighborhood you want to stay in. There are obvious advantages to staying in a hotel within easy walking distance of the main sights. If a picturesque location is your main concern, stay in one of the small hotels around Piazza Navona or Campo de' Fiori. If luxury is a high priority, head for Piazza di Spagna or beyond the city center, where quality/price ratios are higher and some hotels have swimming pools.