The Upper Galilee and the Golan are a 1½-hour, 60-km (37-mile) drive from both Akko and Nahariya; a three-hour, 180-km (112-mile) drive from Tel Aviv; and three hours from Jerusalem, which is 200 km (124 miles) to the south.
There are a few different ways to get here. From Tiberias and the Sea of Galilee, Route 90 runs north between the Hula Valley, on the east, and the hills of Naftali, on the west. The more rugged Route 98 runs from the eastern side of the Sea of Galilee up through the Golan Heights to Mount Hermon. Near the top of Route 98 you can pick up Route 91, which heads west into the Upper Galilee.
From the Mediterranean coast there are several options, but the main one is Route 85 from Akko. Route 89 runs parallel to Route 85 a little farther north, from Nahariya, and has some gorgeous scenery.
From Haifa, take Route 75 to Route 77, turning onto Route 90 at Tiberias, or Route 70 north onto Route 85 east. If you're starting from Tel Aviv, drive north on Route 4 or 2 to Hadera; from there you'll head northwest on Route 65, exiting onto Route 85 east.
The state of Israel's roads is generally fair to good, but in the Upper Galilee some roads are still two-lane. Drive cautiously. Try to avoid driving during peak hours (usually late Thursday and Saturday afternoons), when city folk crowd the roads back to Jerusalem and Tel Aviv after a day out in the country.