Among my favorites:

Cities: Seattle, Portland, Boston, San Franciso, Manhattan

Small towns: Sedona, AZ; Ouray, CO; Crested Butte, CO

National Parks: Glacier, Grand Canyon, Zion, Olympic

Beaches: Cape Cod, Sanibel, Siesta Key, Olympic NP, Oregon coast, Bermuda

Just wonderful thinking about them:
San Francisco and The Bay Area
New York City
The Pacific Northwest, including Central OR and the Cascade Range, Vancouver, San Juan Islands, I could go on and on.
Grand Canyon
Let us know as you narrow it down. Have fun!

ALL of them!
It seems no matter where I visit I want to move there. :-d

Yosemite and New Orleans - how's that for 2 totally different places - LOL.

As it is so often, my last...the Sonoma/Mendocino CA Coast between Gualala and Little River. If you ever get a chance make reservations for the Greenwood Pier Inn in Elk and ask for either the North or South Castle Rooms.
Private cottage with fireplace and jetspa tub (on the 2nd level with a glass surround) and you are RIGHT on the ocean-not nearby, next to, or close-just an incredible view and place on the planet.

Seems like there are a lot of plugs for our National Parks as well as Australia. I'm going to do some more research on the Parks suggestions....

Winner: Ireland, hands down
First runner-up: Alaska
Second runner-up: Las Vegas

in the US -
maui
san francisco
new york city

in Canada -
montreal
niagara falls

abroad -
santorini
paris
amsterdam
southern coast of france

Hawaii, when we can afford it. Vancouver Island, BC, every summer whether we can afford it or not.

Another vote for Nat'l Parks, esp Zion, Bryce, Grand Canyon, north and south rims. Also Indian country driving tour. Start in Phoenix, go through Painted Dessert and the Petrified Forrest, to Canyon de Chelley, a Navajo site w/a nice lodge to stay at and great jeep tours, up to Hopiland, then up to fabulous Monument Valley, back to Phoenix, stopping in Sedona.
Hawaii, but that takes a lot of time and $$. Oh, and how can I forget one of my faves, Death Valley Nat'l Park. Awesome!

Paris, France is top choice. It's a grand city. This is followed by Charleston, South Carolina. Its downtown area has no skyscrapers and it gives you a feeling of how it felt to live there 150 years ago. Quite unique for an American city plus they have preserved many of the homes from the pre-Civil War period. A snapshot in time preserved. Lastly, Sedona, Az. The red mountains are truly unique.

Where we haven't been before. Somewhere new to inspire us. We can relax anywhere and do, but also want to experience something new.

Had to revisit this thread to add Rome, my absolute favorite Europian city.

Florida
Jamaica (at an awful all inclusive :D )
Rome
NYC
Most of the east coast

Pretty much anywhere but Utah or France or a cruise

Hong Kong, Cambodia, VietNam, Laos, Spain, Turkey.

I'll rate mine as they appear on my personal "first place I'll go BACK to" list, as I still try not to repeat my major trip destinations (except NYC, as it is awesome), because there's just too much out there to see:

Alaska
Yellowstone/Tetons
Austria
Costa Rica
Hawaii: Big Island first (love volcanoes), then Kauai, Maui
Any other US Nat'l Park
Germany, esp. Dresden, Bamberg
San Francisco
Wash. DC
Toronto

On my multiple visit list, I'd put NYC, Charleston, western NC mountains, Outer Banks at the top.

You've really gotta do your own research so as to determine what may make YOUR heart LEAP.

Key West, FL

all national parks

My all time favorite is Hawaii - I just can't get enough of that gorgeous place!