Howman37 - With only one overnight stay, I would probably pick Venice over Florence for the single night stay. Don't get me wrong, Florence is wonderful at night, but an overnight in Venice would really let you see a unique city without so many people.

When in comes to important museum reservations, why take the chance of not getting a ticket and reservation for everyone in advance? If this is a once in a lifetime trip, it is worth the small expense. Furthermore, getting a free ticket could be more trouble than it's worth if it includes an additional trip to the admission office etc. instead of just paying for the ticket online. Why take the chance?

You might want to read through these comments from another forum:
https://community.ricksteves.com/tra...s-for-florence

And here is the information from the Vatican Museums about offering free admission to all visitors "with certified invalidity of more than 74%."
Accessibility - Vatican Museums

Good luck with your decisions!

Unless the person using the knee scooter can do a little bit of walking, he/she would have a tougher time in Venice than Florence. Venice has lots of bridges with multiple steps up and down. Getting on and off most trains will be difficult as well.

Italy has come a long way in making buildings accessible, but don't expect the degree of accessibility that you'd find in the U.S. because of the ADA. Lots of old buildings just can't be easily adapted.

When someone has only a few hours in Florence, as this person does, I don't think it's advisable to make any reservations. That doesn't mean I think you should wait in line to get into any museums, Florence has half a dozen extraordinary museums, two of which are much in demand and require reservations if you want to skip the line. Florence also has dozens of churches, where some its most famous art is on display. For maybe two of those reservations are advisable.

My advice on such a short trip is to spend most of your time walking around the center, enjoying the Duomo from the outside, crossing the Ponte Vecchio, and walking along the Arno. This would occupy most of your time, and none of it requires a reservation. You could squeeze in one smaller museum and a few churches, but I recommend skipping anything that requires a reservation. If you have a reservation for something at 4 PM. let's say, your total time is chopped up by the need to get to that place at a specific time.

If you'll be spending the night in Florence, I recommend taking a bus in the late afternoon or early evening up to the Basilica of San Miniato, where there are spectacular views of the city, and the 1000-year-old church itself is very beautiful, with a splendid 13th-century mosaic in the apse. San Miniato is higher up than Piazzale Michelangelo, but they're very near one another.

Then get up in early the next morning to enjoy the walk along the Arno suggested by 5alive.

You are so right, Jean! When visiting Venice with my mom, I specifically used a backpack so I could lift and carry my mom's suitcase over all of the bridges. That in itself was pretty challenging. Venice would be quite difficult with a knee scooter on foot. Uff...

Hi, I was in Florence and Pisa last September.
Pisa takes at least half day and everything to do is in one place, the tower, the Duomo, the baptistery and the camposanto. ALL worth visiting and you need
to book a time to enter the tower. Look for the online site of the tower and you can pay the entrance fees for everything. I went on my way from Florence to Rome.
Went by train, arrived 0900 am and at 2pm was taking the train to Rome. And was told Lucca, nearby is also worth visiting, more than Pisa as a town. If you have just ONE day stay in Florence. Go and see The David, you can have an evening free walking tour in Florence.

A couple of Florence's old markets are worth a quick look:


Florence's Central Market of prepared foods and vegs is interesting to look around and have a cheap lunch of downhome Ialian foods in the restaurant stalls with just a few seats. Good place for picnic stuff too.

https://www.yelp.com/biz/mercato-cen...enze-firenze-2

https://www.google.com/search?q=flor...ih=625&dpr=1.5

At the Mercato Nuovo, an ancient market built by Cosmo de Medici that now sells leather good and tourist souvenirs, has one Florence's most famous statues - that of a bronze boar in a tiny fountain that folks throw coins into its jaws - if the coins stay in the jaw you have good luck but if they bounce out of jaw or miss mark it's bad news (see link below) -has become extremely popular and right in historic centre not far from Ponte Vecchio don't miss this delight.

The porcellino of Florence, the luckiest Florence attraction

I believe this person meant to type Florence, not Venice, as 5alive mentioned the Fra Angelico works in his/her post.

Yes, my mistake, I meant to type Florence.

Pisa's wonders extend far beyond the golden field, much of the city walls and towers are still there north of the river while the town has a number of fine old religious buildings to the North East worth a walk in. I do accept that the area around the railway system is pretty poor. "All in one place" I think not. ;-)