A car is definitely the best way to see El Norte Grande. Driving in the cities can be a little hectic, but highway travel is usually smooth sailing and the roads are generally well maintained. Ruta 5, more familiarly known as the Pan-American Highway, bisects all of northern Chile. Ruta 1, Chile's answer to California's Highway 101, is a beautiful coastal highway running between Antofagasta and Iquique. Avis, Budget, and Hertz all have car rental offices in the region.