To reach the East Bay from San Francisco, take Interstate 80 East across the San Francisco–Oakland Bay Bridge. For U.C. Berkeley, merge onto Interstate 580 West and take Exit 11 for University Avenue. For Oakland, merge onto Interstate 580 East. To reach downtown, take Interstate 980 West from Interstate 580 East and exit at 14th Street. Travel time varies depending on traffic, but should take about 30 minutes (or more than an hour if it's rush hour).
For all points in Marin, head north on U.S. 101 and cross the Golden Gate Bridge. Sausalito, Tiburon, the Marin Headlands, and Point Reyes National Seashore are all accessed off U.S. 101. The scenic coastal route, Highway 1, also called Shoreline Highway and Panoramic for certain stretches, can be accessed off U.S. 101 as well. Follow this road to Muir Woods, Mt. Tamalpais State Park, Muir Beach, Stinson Beach, and Bolinas. From Bolinas, you can continue north on Highway 1 to Point Reyes.