To reach the East Bay from San Francisco, take Interstate 80 East across the San Francisco–Oakland Bay Bridge. Head east from the University Avenue exit to reach U.C. Berkeley; there's a parking garage on Channing Way near the campus. For Oakland, take Interstate 580 off the Bay Bridge. To reach downtown and the waterfront, take Interstate 980 from Interstate 580 and exit at 12th Street. Both trips take about 30 minutes unless it's rush hour or a weekend afternoon, when you should count on an hour.
Head north on U.S.101 and cross the Golden Gate Bridge to reach all points in Marin by car, essential to visit the outer portions unless you want to spend all day on the bus. From San Francisco, the towns of Sausalito and Tiburon and the Marin Headlands and Point Reyes National Seashore are accessed off U.S. 101. The coastal route, Highway 1, also known as Shoreline Highway, can be accessed off U.S. 101 as well. Follow this road to Mill Valley, Muir Woods, Mt. Tamalpais State Park, Muir Beach, Stinson Beach, and Bolinas. From Bolinas, you can continue north on Highway 1 to Point Reyes. Depending on traffic, it takes from 20 to 45 minutes to get to the Marin Headlands, Sausalito, and Tiburon; driving directly to Point Reyes from San Francisco takes about 90 minutes in moderate traffic if you drive north on U.S. 101 and west on Sir Francis Drake Boulevard. Trips to Muir Woods take from 35 minutes to an hour from San Francisco. Add another 30 minutes for the drive to Stinson Beach (the curving roads make the going slower), 10 more if you continue on to Bolinas. The drive from Bolinas to Point Reyes takes an additional half hour.