Both districts are about a half-hour drive from Central Tucson. To reach the Rincon Mountain District (East section) from Interstate 10, take Exit 275, then go north on Houghton Road for 10 miles. Turn right on Escalante and left onto Old Spanish Trail, and the park will be on the right side. If you're coming from town, go east on Speedway Boulevard to Houghton Road. Turn right on Houghton and left onto Old Spanish Trail.
To reach the Tucson Mountain District (West section) from Interstate 10, take Exit 242 or Exit 257, then go west on Speedway Boulevard (the name will change to Gates Pass Road), follow it to Kinney Road, and turn right.
As there’s no public transportation to or within Saguaro, a car is a necessity. In the western section, Bajada Loop Drive takes you through the park and to various trailheads; Cactus Forest Drive does the same for the eastern section.