Public buses to and within this entire region are punctual and economical, and local shuttles from San José can drop you off at your hotel's doorstep. Public buses leave San José almost hourly between 6 am and 7:30 pm and take four hours to reach Quepos. From here you have to take local transportation to your hotel in Manuel Antonio. Gray Line and Interbus are more direct, with hotel pickup in San José and Quepos or Manuel Antonio. Both companies offer a morning and afternoon trip for around $52 one way.
Gray Line. 2220–2126; 800/719–3905; www.graylinecostarica.com.
Interbus. 4100–0888; www.interbusonline.com.