Although Mt. Rigi and Mt. Pilatus aren't accessible by car, nearly everything else in this region is.
The descent from Andermatt past the Devil's Bridge, which once carried medieval pilgrims from the St. Gotthard Pass and drew thrill-seekers during the 19th century, now exemplifies awe-inspiring Swiss mountain engineering: from Göschenen, at 3,627 feet, to the waterfront, it's a four-lane expressway.
Keep in mind, many of the towns in this region are scattered around the unusually shaped Vierwaldstättersee, so sometimes a ferry will be faster than a freeway.