The densely populated coast around Porto and the Minho region are well served with roads. A half-hour drive on the A3/IP1 toll highway will take you from Porto to Braga (for Guimarães, peel off just beyond halfway on the A7/IC5) before continuing on to Ponte de Lima and Valença on the Spanish border. The IC1 hugs the coast from Porto almost directly north to Viana de Castelo—a drive of just over an hour.
Inland, the A4/E82 toll road connects Porto to Amarante—again, a drive of about an hour. From here the three-lane IP4/E82 passes through Vila Real, Mirandela, and Bragança en route to the Spanish border at Quintanilha—in all, about four hours from Porto. The IP3 comes up from Viseu in the Beiras through Lamego to Peso da Régua and then Vila Real. You can continue north to Chaves on the N2.